You are here

One stressful event blocks multiple actions of diazepam for up to at least a month

Antelman SM, Knopf S, Kocan D, Edwards DJ, Ritchie JC, Nemeroff CB. One stressful event blocks multiple actions of diazepam for up to at least a month. Brain Res 1988, 445(2):380–385.

Based on recent findings of this laboratory, the hypothesis was tested that a single stressfulencounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect ofdiazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.