Natural History.
      Parthenium hysterophorus.
      Escoba amarga.
      N. O. Composite (tribe Helianthee).
      Tincture of the dry plant.
      Trituration of solution of the alkaloid Parthenia.

      Cheyne-Stokes breathing. Debility.
      Ear, affections of.
      Headache, extending to nose.
      Liver, pain in.
      Milk, increased, Neuralgia, periodic. Salivation.
      Spleen, affection of.
      Vision, disordered.

      E. Fornias brought Parthen. to light (H.R., i. 42, 71).
      It is a Cuban remedy of great repute in the treatment of fevers.
      An alkaloid Parthenia was isolated by C. J. Ulrice, of Havana, and Dr. J. L. Duenas published experiments with this on the human organism and on animals.
      Dr. B. H. B. Sleight proved increasing doses of the tincture, and later on of 6x, which reproduced most of the symptoms of the first proving.
      The Schema is made up chiefly of Sleight’s symptoms, additions from Duenas being marked (D).
      Dr. Ramirez Tovar has reported these cures by Parthenia: (I) A lady living in the lower part of the city, where the rain leaves channels of infection, had daily attacks of intermittent, more intense each day.
      One grain of the alkaloid was divided into six powders, one every hour after the attack.
      No further attacks.
      The patient was nursing at the time, and she noticed a marked increase of milk in the breasts.
      Half a grain divided into five doses completed the cure.
      (2) A tailor, 30, moved to lower part of the city, and contracted tertian intermittent, the fourth seizure being attended with much pain in left hypochondrium.
      One grain in five doses cured, though the conditions were unchanged.
      (The removal of this left hypochondriac pain is important in connection with Burnett’s experience with Helianthus.) (3) Girl, 6, lymphatic, living near the harbor, ill for seventeen days with malaise, loss of appetite, sleepiness, and fever.
      Had had Quinine internally and externally and was wasting visibly.
      The alkaloid, aided by a tonic wine prepared from the extract of the plant, cured (4) Man, 45, of delicate constitution, poorly nourished, straw-yellow face, yellow sclerotics, enlarged liver and spleen, spleen painful to pressure.
      Had had fever in Panama, had taken Quinine, complained of a pain in right side (more severe in some parts than in others), which commenced one PM with shiverings, disappeared in two hours, and returned at precisely the same hour next day.
      Five doses of ten centigrams each removed the pain.
      About six weeks later there was a relapse, the pain this time being located in the stomach.
      One grain in five doses, one dose every two hours, removed the pain, but it returned the third day.
      The same treatment then removed it permanently.
      (5) Young lady, 18, had periodical facial neuralgia, cured by same treatment.
      Fornias adds this case: His niece, 5, living in Havana, had been suffering from a continued fever with periodical midday exacerbations, which later on assumed an intermittent form.
      She had been saturated with Quinine, and complained at the time of malaise, lassitude, headache, gastric intolerance, etc., when she was seen by Dr., Govantes, who prescribed an extract of Parthen. hyst., three doses a day, each the size of a pea.
      In four or five days she was free from fever, and made a quick recovery.
      In the proving the pains were sudden, congestive, out-pushing.
      A large number were experienced in the head and ears, and singing and fullness in the ears was among them, which points to its antidotal action towards Quinine. The symptoms were worse by sudden motion, worse after sleep, worse after getting up and going about.

      It antidotes Quinine.
      Compare: In spleen affections, Helianth., Cean. In malaise and periodic neuralgia, Malar. Off., Chi., Cedr.

      Feels dull and stupid – Difficult to fix attention.
      Malaise, apathy, lassitude (D).
      Indifference (D).

      Vertigo, whole sitting, with heat of face and blurred vision.
      Heaviness and dulness of head.
      Full feeling, esp., in vertex, pressing from within.
      Stitching pain in left temple, of short duration.
      Aching pain at left supraorbital foramen.
      Head heavy, brain feels loose, worse moving head.
      Headache feels as if in a vice.
      Sudden stitching and severe plunging pain in left frontal eminence.
      On rising, after restless nigh, throbbing deep brain as if is would push through top of head, "big head," better after moving about and washing face.
      Sudden darting pains in right, then left, frontal eminence, worse by sudden movement.
      Head feels swelled, brief feeling as if blood would burst through face, returning in a few minutes, especially above nose and root of nose.
      Heart beat felt all over head and over eye, worse motion.
      Pressure at right frontal eminence, increasing to sharp, penetrating pain, going to root of nose, then to tip, where it is most severe, restlessness succeeds, seems in all bones of nose.
      Worse left
      Front of head feels big.

      Eyes heavy, drowsy.
      Aching in eyeballs.
      Must look intently to see the words, when writing the letters seem pale and eye ache.
      Aching over eyes, wants to close them.

      Ringing in ears, worse left
      Some sharp pain in ears.
      Aching at lower edge right ear spreads over face, ear feels plugged up.
      Stitching at lobe of left ear, deep in and above external auditory meatus.
      Dullness and aching in ears, coming suddenly.
      Splitting pain over both ears in spots size of a dollar.
      Stabbing pain in left ear.
      Singing, dull aching, pushing out in left ear.

      Pain at root of nose and in nose, in all bones of nose, worse left
      At root of nose stuffed feeling as with dry coryza.
      Nose feels swollen, and tender to touch.
      Aching in bridge of nose (worse left side) and of upper left molars.
      Aching at end of nose, which feels full of blood.

      Bursting pain in right malar bone.
      Seems as if bloods would burst through face.
      Aching pains run up from above left eye-tooth to eye and over face, occurs by starts and stops.

      Upper teeth feel on edge, pricking pains in sockets.
      Head thick, heavy.
      Sharp aching twinges in upper molars.
      Upper incisors tender at sockets when biting.
      Sharp pain in left upper and lower molars.
      Teeth feel too long.
      Tingling in tip of tongue.
      Profuse, very fluid salivation.

      Goneness in epigastrium, hunger.
      Irrepressible, tasteless eructations.
      Eructations tasting of the drug.
      Head lumps at epigastrium.
      Heat and weight in stomach.

      Severe pain in left hypochondrium, with tertian fever (cured with Parthenia).
      Spleen painful to pressure, pain in right side, worse in some parts than in others, with shiverings I PM daily (cured with Parthenia).
      Loud rumbling in bowels, about navel.
      Slight colicky pains at navel.
      Colic deep in pelvis, pains run down backs of thighs to knees.

Stool and Anus.
      Stabbing pain runs up rectum after passing flatus.
      No desire at usual time, (10 AM) 10.30 PM mushy stool.

Urinary Organs.
      Kidneys enlarged and congested (D).
      Increased urine.

Female Sexual Organs.
      Given to pregnant women for febrile conditions, it has caused abortion and premature delivery (D).
      Given in a case of subacute tuberculosis, it restored the menses, which had been absent since the illness commenced.
      Great increase of milk in breasts of nursing women cured with Parthenia of intermittent fever.

Respiratory Organs.
      Slow, irregular (Cheyne-Stokes) breathing (D).

      Excitation of heart-beast, or slow heat (D).
      Progressive slowness of pulse, followed by syncope, cardiac paralysis, and death (D).
      Pulse slow, soft compressible.

Upper Limbs.
      Hands feel numb, especially their dorsa.

Lower Limbs.
      Pains run from pelvis down backs of thighs to knees.
      Marked diminution of reflex in hips and extinction of voluntary movements (D).

      Tremors (D).
      Muscular relaxation, anesthesia (D) coagulation of blood retarded (D).
      The alkaloid is very rapidly absorbed and eliminated.
      General depression and lassitude.

      Restless night, wakes at 3 and four AM, then dozes and dreams till 7.30.
      Increased stupor, desire to be quiet (D).

      Rise and fall of temperature, shivering, diminished perspiration (D).